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Bismuth subsalicylate may cause a temporary and harmless darkening of the tongue and/or black stool.
Concomitant administration of drugs for anticoagulation, gout or diabetes.
Previous hypersensitivity to nonsteroidal anti-inflammatory agents. Patients with gout, diabetes, bleeding ulcers, hemophilia or other hemorrhagic conditions, or renal insufficiency (due to salicylate component). Patients with colitis or other gastrointestinal mucosa abnormalities which may enhance bismuth absorption. Rare reports of neurotoxicity with excessive dose of bismuth subsalicylate.
Bismuth may interfere with radiologic examinations in gastrointestinal tract.
Impactation may occur in debilitated patients.
Patient with renal impairment.
Use in Lactation: Concern only goes with high doses and chronic use because salicylate intake of infant may occur.
Use in Children: Caution in use of bismuth subsalicylate in infants and children (greater risk of impaction and salicylate toxicity). Children and teenagers who have or are recovering from influenza or varicella.
